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What Is Spravato and Why It’s a Game Changer for Depression Treatment

Medically reviewed by: Dr. Peck
Reading Time: 2 minutes

Depression is a debilitating mental illness that can take a significant toll on a person’s life. Despite the numerous therapies and treatments available, some individuals face challenges trying to manage the symptoms of depression using conventional approaches. Fortunately, there’s a new treatment option for patients with treatment-resistant depression – Spravato. In this blog post, we dive into how Spravato works and why it’s a potential game-changer for those who struggle with depression.

What is Spravato?

Spravato, also known by its generic name esketamine, is a nasal spray that received approval from the U.S. Food and Drug Administration (FDA) in 2019 as a treatment option for individuals with treatment-resistant depression. The drug is derived from ketamine – a powerful anesthetic that’s been in use since the 1970s. Spravato is administered under the supervision of a healthcare professional in a clinical setting, typically as part of a comprehensive treatment plan that includes counseling and therapy.

How does Spravato work?

The exact mechanism by which Spravato works is still unknown, but it is believed to target the glutamate system in the brain to improve symptoms of depression. Unlike traditional antidepressant drugs that may take several weeks to begin working, Spravato often provides relief within hours or days of administration. Treatment involves an initial set of sessions in which the drug is administered twice a week for four weeks, followed by weekly or bi-weekly maintenance doses as needed.

How long does Spravato last?

The effects of Spravato can last anywhere from several days to a few weeks, although the duration of effectiveness may vary depending on individual circumstances. It’s essential to follow the treatment schedule precisely as prescribed by a healthcare provider and communicate any side effects that may arise.

Our Final Thoughts On Spravato

Spravato is a promising new treatment option for people with treatment-resistant depression. With its fast-acting mechanism and the ability to complement traditional therapies, it offers hope for individuals who have exhausted conventional approaches. Although the drug is only administered under the supervision of a healthcare professional, clinical trials have shown that it is well-tolerated and relatively safe. If you’re struggling with depression, talk to your doctor about Spravato to see if it may be a potential solution for you.