Ketamine is medication and has been used as an anesthetic since the 1970s in both operating rooms and for treating soldiers during the Vietnam War. However, for almost as long, it has been explored for its benefits in treating depression, PTSD, OCD, chronic pain, and other debilitating conditions. In fact, it has been called “one of the biggest breakthroughs in depression management.”
Ketamine demonstrates significant effectiveness in treating these conditions, including treatment-resistant depression, which affects one in three depression patients and does not respond to conventional medications and talk therapy. Now there is hope and help!
As an NMDA receptor antagonist, ketamine binds to NMDA receptor proteins located on cell membranes. Here, it can block glutamate from binding. Ketamine also affects the mTOR pathway, which is how it is thought to help create new neural connections. It also binds to the AMPA receptor and opioid receptors.
By boosting/enhancing neural activity, ketamine helps the brain operate normally. Ketamine improves neuroplasticity, which is critical for patients to overcome unhealthy, recursive patterns.
Depression is set to be the leading cause of disability in the world. With depression on the rise people are turning to alternative medicines and psychedelic therapies when traditional medications fail them.
Psychedelics refer to synthetic and plant-based substances that alter the state of consciousness, often being so unique and powerful that they’re compared to religious experiences. Psychedelics create an altered state of consciousness, this altered state allows you to distance yourself from your trauma and examine how it affects you and how to create a safe space for you to work through them.
Ketamine’s rapid-acting antidepressant effects are widely considered one of the biggest breakthroughs in mental health in two decades.
Patients can feel relief in hours or days, versus several weeks or months when treated with conventional antidepressant.
Ketamine works differently from traditional SSRI’s or SNRI’s. When traditional antidepressants fail, it’s time to try a new treatment.
If you’re wondering how does Ketamine work, it works very differently in the brain than other drugs. It stimulates the formation of new neural connections, which helps to make the brain more adaptable and flexible while supporting the development of new behaviors and even new thought pathways. Ketamine also blocks glutamate, which has been shown to cause depressive symptoms.
If you have tried more than one traditional medications such as antidepressants and or talk therapy, with little relief from your symptoms, ketamine therapy may be right for you.